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Influence of early day-care exposure on total IgE levels through age 3 years

Janet Rothers1, Debra A Stern, Amber Spangenberg

  • 1Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA.

The Journal of Allergy and Clinical Immunology
|September 15, 2007
PubMed

Insights

Early day care by 3 months is linked to lower total immunoglobulin E (IgE) levels in children up to age 3. This effect is most pronounced in infants with atopic or asthmatic mothers, potentially reducing allergy risk.

Area of Science:

  • Immunology
  • Pediatrics
  • Environmental Health

Background:

  • Early day care is linked to reduced asthma and atopy later in childhood.
  • The association between early day care and immunological markers of asthma risk is not well understood.

Purpose of the Study:

  • To investigate the relationship between day care attendance by 3 months of age and total immunoglobulin E (IgE) levels up to 3 years.
  • To determine if early day care exposure influences early immunologic markers of asthma risk.

Main Methods:

  • Prospective study of 362 infants in the Infant Immune Study.
  • Infants categorized by day care status (none, inside home, outside home).
  • Total IgE levels measured at 3, 12, 24, and 36 months; analyzed longitudinally and stratified by maternal history of asthma/atopy.

Main Results:

  • Day care by 3 months was associated with significantly decreased total IgE levels through age 3 (P = .001).
  • The strongest association was observed for children in day care outside the home.
  • This association was primarily seen in infants of mothers with asthma or atopy.

Conclusions:

  • Early day care attendance (by 3 months) is associated with reduced total IgE levels in the first three years of life.
  • This reduction in IgE may indicate a decreased risk of allergic diseases in genetically predisposed children.
  • Early day care exposure could be a protective factor for allergic conditions in at-risk infants.
Abstract

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