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Updated: Jul 11, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Maternal and neonatal tetanus.

Martha H Roper¹, Jos H Vandelaer, François L Gasse

¹Weybridge, VT, USA.

Lancet (London, England)

|September 15, 2007

Summary

Maternal and neonatal tetanus cause significant global mortality, particularly in developing nations. Preventing these diseases requires widespread tetanus toxoid vaccination and improved healthcare infrastructure for long-term elimination.

Area of Science:

Public Health
Infectious Disease Prevention
Global Health Security

Background:

Maternal and neonatal tetanus (MNT) contribute significantly to global maternal and neonatal mortality, with approximately 180,000 deaths annually, predominantly in developing countries.
Despite effective prevention methods like maternal immunization with tetanus toxoid vaccine and aseptic care practices, MNT remains a persistent public health issue in 48 countries, primarily in Asia and Africa.

Purpose of the Study:

To highlight the ongoing burden of maternal and neonatal tetanus globally.
To emphasize the role of the Maternal and Neonatal Tetanus Elimination Initiative in supporting countries towards MNT elimination.
To underscore the necessity of robust healthcare infrastructures and universal service access for sustained MNT elimination.

Main Methods:

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Last Updated: Jul 11, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Review of global mortality data related to maternal and neonatal tetanus.
Description of the strategies employed by the Maternal and Neonatal Tetanus Elimination Initiative.
Analysis of factors contributing to the persistence of MNT and requirements for long-term elimination.

Main Results:

Maternal and neonatal tetanus cause substantial mortality, with nearly all deaths occurring in developing countries.
Improved survival rates for tetanus patients in hospitals with intensive care are noted, but these facilities are often inaccessible in high-burden areas.
The Maternal and Neonatal Tetanus Elimination Initiative is actively working to provide tetanus toxoid immunization to women of childbearing age in endemic regions.

Conclusions:

Worldwide elimination of maternal and neonatal tetanus is the ultimate goal.
Sustaining MNT elimination necessitates improvements in immunization and health-service infrastructures, alongside universal access to these services.
Global commitment to reducing maternal and child mortality can drive the systemic changes required for long-term MNT elimination.