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Twin fetuses with abnormalities that overlap with three midline malformation complexes
S R Hingorani1, R A Pagon, T H Shepard
1Department of Pathology, University of Washington, School of Medicine, Seattle 98195.
American Journal of Medical Genetics
|November 1, 1991
Summary
This study details twin fetuses with concordant oral, facial, skeletal, and central nervous system malformations. Phenotypic overlap with known genetic syndromes is discussed.
Area of Science:
- Medical Genetics
- Developmental Biology
- Teratology
Background:
- Congenital malformations present a significant challenge in prenatal diagnosis.
- Differentiating between syndromes with overlapping phenotypes is crucial for accurate genetic counseling and management.
- Twin gestations can exhibit complex patterns of discordance and concordance in anomalies.