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[Malignant hyperthermia today].

N Roewer1

  • 1Abteilung für Anästhesiologie, Universitäts-Krankenhaus Eppendorf, Hamburg.

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|December 1, 1991
PubMed
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Malignant hyperthermia (MH) is a rare, life-threatening reaction to certain anesthetics. This review covers new genetic and pathogenesis insights for malignant hyperthermia, aiding susceptibility identification and treatment.

Area of Science:

  • Anesthesiology
  • Genetics
  • Pathology

Context:

  • Malignant hyperthermia (MH) is a critical pharmacogenetic disorder.
  • Understanding MH triggers, genetics, and pathogenesis is crucial for patient safety.

Purpose:

  • To provide a comprehensive review of malignant hyperthermia (MH).
  • To highlight recent advancements in MH genetics and pathogenesis.
  • To consolidate information on MH diagnosis, treatment, and prophylaxis.

Summary:

  • This review details the history, epidemiology, genetics, and pathogenesis of malignant hyperthermia (MH).
  • It covers triggering agents, clinical manifestations, associated disorders, and diagnostic strategies.
  • Emphasis is placed on molecular genetics, pathogenesis, and identifying susceptibility.

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Impact:

  • Improved understanding of malignant hyperthermia (MH) for clinicians and researchers.
  • Enhanced strategies for MH diagnosis, susceptibility testing, and emergency management.
  • Potential for improved patient outcomes through better prophylaxis and treatment protocols.