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[Morpho-functional changes in the lymph nodes during fever reaction].

M M Minnebaev, F I Mukhutdinova

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |August 1, 1991
    PubMed
    Summary
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    Rabbit lymph nodes show increased activity during fever, with more lymphocytes and immune cells. This suggests enhanced cellular and humoral immunity, despite some cell destruction observed.

    Area of Science:

    • Immunology
    • Pathology
    • Veterinary Medicine

    Background:

    • Lymph nodes are crucial for immune responses.
    • Fever is a complex physiological reaction involving immune system activation.
    • Understanding lymph node dynamics during fever is key to immune function.

    Purpose of the Study:

    • To investigate morpho-functional changes in rabbit lymph nodes during fever.
    • To correlate these changes with immune system activity.
    • To assess the impact of fever duration on lymph node responses.

    Main Methods:

    • Histological examination of mesenteric, popliteal, and cervical lymph nodes from rabbits experiencing fever.
    • Analysis of cellular hyperplasia, lymphoid cell populations, and macrophage activity.

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  • Assessment of plasma cell differentiation and PAS-positive cell presence.

    • Main Results:

    • Increased functional activity in lymph nodes during fever.
    • Hyperplasia of lymphatic tissue, increased lymphocytes, and lymphoid cells in follicles and paracortical zones.
    • Evidence of macrophagal reaction, plasmatization, lymphocytolysis, and increased PAS-positive cells.

    Conclusions:

    • Fever induces significant morpho-functional changes in lymph nodes, enhancing immune readiness.
    • Observed changes support increased cellular and humoral immunity.
    • Fever triggers both immune activation and cellular destruction within lymph nodes.