Related Experiment Video
Updated: Jul 11, 2026

Sealable Femtoliter Chamber Arrays for Cell-free Biology
Published on: March 11, 2015
Effects of the DNA state fluctuation on single-cell dynamics of self-regulating gene
Yurie Okabe1, Yuu Yagi, Masaki Sasai
1Department of Computational Science and Engineering, Nagoya University, Nagoya 464-8603, Japan.
Abstract:
A dynamical mean-field theory is developed to analyze stochastic single-cell dynamics of gene expression. By explicitly taking account of nonequilibrium and nonadiabatic features of the DNA state fluctuation, two-time correlation functions and response functions of single-cell dynamics are derived. The method is applied to a self-regulating gene to predict a rich variety of dynamical phenomena such as an anomalous increase of relaxation time and oscillatory decay of correlations. The effective "temperature" defined as the ratio of the correlation to the response in the protein number is small when the DNA state change is frequent, while it grows large when the DNA state change is infrequent, indicating the strong enhancement of noise in the latter case.
More Related Videos
09:17Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
Published on: March 1, 2022
17:01Acquiring Fluorescence Time-lapse Movies of Budding Yeast and Analyzing Single-cell Dynamics using GRAFTS
Published on: July 18, 2013
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Gene Evolution - Fast or Slow?
In contrast, regions which code...
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...