Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment inequity among older adults with newly diagnosed acute myeloid leukemia ineligible for intensive therapy.

Leukemia & lymphoma·2026
Same author

QuANTUM-Wild: a Phase III, randomized trial of quizartinib in newly diagnosed <i>FLT3</i>-ITD-negative acute myeloid leukemia.

Future oncology (London, England)·2026
Same author

Outcomes of patients with higher-risk myelodysplastic syndromes/neoplasms treated with hypomethylating agents + venetoclax-an analysis from the International Consortium for MDS (icMDS) VALIDATE database.

Blood cancer journal·2026
Same author

Real-world, multi-omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS).

HemaSphere·2026
Same author

Beyond the Catalogue: Design and Biological Enrichment as the Next Priorities in Higher-Risk MDS Drug Development.

European journal of haematology·2026
Same author

Menin inhibitors for patients with relapsed/refractory acute myeloid leukemia (AML): a systematic review and meta-analysis.

Leukemia & lymphoma·2026

Related Experiment Video

Updated: Jul 11, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Platelet function testing: state of the art.

Amer M Zeidan1, Peter A Kouides, Mary Ann Tara

  • 1Division of Hospital Medicine, Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA. amer.zeidan@viahealth.org

Expert Review of Cardiovascular Therapy
|September 18, 2007
PubMed
Summary

Platelet function testing has advanced, but current methods lack standardization and specificity. Newer tests are replacing older ones for screening bleeding disorders and monitoring antiplatelet drugs.

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Related Experiment Videos

Last Updated: Jul 11, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Platelet function testing has evolved significantly from basic methods like bleeding time.
  • Existing tests often suffer from poor specificity, sensitivity, and standardization issues.

Purpose of the Study:

  • To review the evolution and current state of platelet function testing.
  • To highlight the shift towards more sophisticated diagnostic tools and drug monitoring.

Main Methods:

  • Review of current literature and common laboratory practices in platelet function analysis.
  • Comparison of traditional methods (bleeding time, aggregometry) with newer technologies (Platelet Function Analyzer-100, flow cytometry).

Main Results:

  • The bleeding time test is being phased out in many labs due to limitations.
  • The Platelet Function Analyzer-100 is increasingly used for bleeding disorder screening.
  • Platelet aggregometry and lumiaggregometry remain valuable for mechanistic insights.
  • Flow cytometry offers detailed assessment but is often limited by cost.

Conclusions:

  • Platelet function testing has advanced, offering better insights into platelet activity.
  • There is a growing demand for tests that can screen bleeding disorders and monitor antiplatelet drug efficacy.
  • Future advancements in understanding platelet pathways will likely drive further demand for specialized testing.