Onycholysis induced by nail hardener
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Updated: Jul 11, 2026

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
Published on: November 13, 2016
Per Helsing1, Joar Austad, Hans Jørgen Talberg
1Department of Dermatology, Rikshospitalet University Hospital, 0027 Oslo, Norway. per.helsing@rikshospitalet.no
Abstract:
Nail hardeners appeared in the market during the 1960s. They were basically solutions of formaldehyde. The first adverse effects were published in 1966 (1). Reactions were onycholysis, chromonychia, subungual haemorrhage, and hyperkeratosis. Onycholysis may be non-inflammatory or inflammatory, and is accompanied by throbbing pain. Inflammatory reactions are followed by paronychia and occasional dermatitis on the digital pulpa.
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