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Related Experiment Video

Updated: Jul 11, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Traditional acupuncture in migraine: a controlled, randomized study.

Enrico Facco1, Aldo Liguori, Filomena Petti

  • 1University of Padua - Department of Medico-Surgical Specialties - Sect. Dentistry, Padua, Italy.

Headache
|September 18, 2007
PubMed
Summary

True acupuncture, guided by traditional Chinese medicine (TCM), effectively improved migraine outcomes compared to sham treatments or no prophylactic therapy. This study highlights TCM acupuncture

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Area of Science:

  • Neurology
  • Integrative Medicine
  • Traditional Chinese Medicine

Background:

  • High migraine prevalence impacts adults during their productive years.
  • Acupuncture is increasingly used for migraine, but evidence remains weak.
  • Inconsistent treatment protocols and lack of TCM-guided acupoint selection may explain low evidence levels.

Purpose of the Study:

  • To evaluate the effectiveness of true acupuncture based on TCM for migraine without aura.
  • To compare true acupuncture against mock acupuncture and untreated controls.
  • To assess the impact of different acupuncture protocols on migraine management.

Main Methods:

  • A prospective, randomized, controlled study involving 160 patients with migraine without aura.
  • Four groups: true acupuncture (TA) + Rizatriptan, ritualized mock acupuncture (RMA) + Rizatriptan, standard mock acupuncture (SMA) + Rizatriptan, and Rizatriptan only (R).

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  • MIDAS Index (MI) assessed at baseline, 3, and 6 months; Rizatriptan intake monitored.

    • Main Results:

    • 127 patients completed the study; baseline MI was moderate to severe across all groups.
    • All groups showed decreased MI, but only the TA group demonstrated significant sustained improvement compared to the Rizatriptan-only group (P < .0001).
    • Ritualized mock acupuncture (RMA) showed a transient improvement at 3 months; Rizatriptan intake paralleled MI changes.

    Conclusions:

    • True acupuncture (TA) was the sole treatment providing consistent outcome improvement over Rizatriptan alone.
    • Ritualized mock acupuncture (RMA) exhibited a transient placebo effect.
    • The findings support the efficacy of TCM-based true acupuncture for managing migraine without aura.