Related Experiment Video
Updated: Jul 11, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Do bullae and emphysema increase risk of pneumothorax in silicosis?
Iraj Mohebbi1, Ebrahim Hassani, Shaker Salarilak
1Department of Occupational Medicine, Urmia University of Medical Sciences, Urmia, Iran. irajmohebbi@umsu.ac.ir.
Background:
The occurrence of occupational lung diseases is decreasing due to improvements in occupational health in recent years; however, silicosis and its complications remain important occupational health problems. We have studied the role of emphysema and bullae as predictive factors of secondary spontaneous pneumothorax in acute and accelerated silicosis.
Methods:
This study was carried out using questionnaire items on occupational history and conventional computed tomography of lungs. Differences between two groups (silicosis with and without secondary spontaneous pneumothorax) in terms of age, interval of exposure-diagnosis and therefore silica exposure duration were assessed by independent t-test. Fisher's exact test was used to determine the association between secondary spontaneous pneumothorax and both emphysema and bullae.
Results:
We found a significant association between secondary spontaneous pneumothorax and bullae in acute and accelerated silicosis.
Conclusion:
Pneumothorax in silicosis could be attributed to previous bullae.
Related Concept Videos
Chronic Obstructive Pulmonary Disease II: Emphysema
Pneumothorax-II
Clinical Manifestations:
Pneumothorax II: Pathophysiology
Pneumothorax-I
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Pleura of the Lungs

