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Related Experiment Videos

[Neonatal lupus erythematosus].

Raquel Coelho1, Manuela Ferreira, Manuel Ferreira

  • 1Departamento de Pediatria, Hospital Fernando Fonseca, Amadora.

Acta Medica Portuguesa
|September 18, 2007
PubMed
Summary
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Neonatal lupus erythematosus (NLE) can cause congenital heart block (CHB), which may resolve spontaneously but often requires a pacemaker. Long-term follow-up is crucial for managing this rare immune condition.

Area of Science:

  • Immunology
  • Pediatrics
  • Cardiology

Background:

  • Neonatal lupus erythematosus (NLE) is a rare autoimmune disorder affecting infants.
  • It is associated with maternal anti-Ro antibodies and can manifest with cardiac, cutaneous, and hematologic issues.
  • Congenital heart block (CHB) is a significant complication of NLE.

Observation:

  • A case of NLE is presented with prenatal diagnosis of bradycardia.
  • The infant was diagnosed with Mobitz type II CHB and left branch block on day one, with no structural heart defects.
  • Spontaneous resolution of CHB occurred before discharge, but complete heart block recurred by three months.

Findings:

  • The infant presented with cutaneous lesions and feeding difficulties at three months.
  • Anti-Ro antibodies were positive in both mother and infant.

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  • Skin biopsy confirmed NLE, and a pacemaker was implanted for the recurrent CHB.

    • Implications:

    • This case highlights the potential for temporary spontaneous resolution of CHB in NLE.
    • It underscores the necessity of long-term cardiac monitoring in infants with NLE.
    • Early diagnosis and intervention, including pacemaker implantation, are vital for managing NLE-related CHB.