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Related Experiment Videos

Hemostasis factors and aging.

Daniela Mari1, Raffaella Coppola, Rita Provenzano

  • 1Department of Medical Sciences, IRCCS Istituto Auxologico Italiano, University of Milan, Italy. daniela.mari@unimi.it <daniela.mari@unimi.it>

Experimental Gerontology
|September 18, 2007
PubMed
Summary
This summary is machine-generated.

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Aging is associated with heightened coagulation enzyme activity, but this hypercoagulability in centenarians is compatible with health and longevity. High coagulation activation markers in older adults may not indicate increased thrombosis risk.

Area of Science:

  • Gerontology
  • Hematology
  • Thrombosis Research

Background:

  • Advancing age is linked to increased laboratory signs of heightened coagulation enzyme activity.
  • This biochemical hypercoagulability may contribute to age-related thrombotic tendency or be a harmless process.
  • Centenarians exhibit pronounced hypercoagulability markers.

Purpose of the Study:

  • To investigate the coagulation status in centenarians.
  • To determine if age-associated hypercoagulability is linked to increased thrombotic risk in the oldest old.
  • To explore the relationship between hypercoagulability, longevity, and atherothrombotic disease markers.

Main Methods:

  • Assessed plasma concentrations of fibrinogen, factor VIII, and other coagulation factors.

Related Experiment Videos

  • Genotyped for PAI-1-675 (4G/5G) polymorphism, factor V (Arg506Gln) mutation, and prothrombin gene G20210A mutation.
  • Measured Von Willebrand factor (VWF) and VWF cleaving proteases; screened for anti-phospholipid antibodies.

    • Main Results:

    • Centenarians showed heightened coagulation enzyme activity, increased fibrin formation, and secondary hyperfibrinolysis.
    • Elevated plasma fibrinogen and factor VIII were observed, alongside a higher frequency of pro-thrombotic genetic risk factors (4G allele, factor V Leiden, prothrombin G20210A).
    • Increased VWF levels and low VWF cleaving proteases were noted in centenarians, along with a high prevalence of anti-phospholipid antibodies.

    Conclusions:

    • The oldest old exhibit hypercoagulability, which is compatible with successful aging and longevity.
    • Elevated coagulation activation markers in the elderly do not necessarily predict a high risk of arterial or venous thrombosis.
    • Age-associated hypercoagulability may represent an adaptive mechanism rather than a pathological state in centenarians.