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Updated: Jul 11, 2026
The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram
Published on: October 10, 2025
Afterdischarges during cortical stimulation at different frequencies and intensities
Gholam K Motamedi1, Oladotun Okunola, Christopher G Kalhorn
1Department of Neurology, PHC 7, Georgetown University Hospital, 3800 Reservior Rd., NW, Washington, DC 20007, USA. Motamedi@georgetown.edu
Purpose:
The occurrence of unwanted afterdischarges (ADs) impedes cortical stimulation for mapping purposes. We investigated the safety of several stimulation paradigms.
Methods:
We compared the incidence of ADs and behavioral responses of two stimulation frequencies (50 and 100 Hz), at two intensities (1 and 0.2 ms pulse widths).
Results:
Stimulation with 100 Hz was more likely to cause ADs than 50 Hz, and stimulation using 1 ms pulse width was more likely to cause ADs than 0.2 ms.
Conclusions:
Stimulation using 50 Hz frequency with a pulse width of 0.2 ms might be safer during cortical mapping.
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