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Updated: Jul 11, 2026

Probing Surface Electrochemical Activity of Nanomaterials using a Hybrid Atomic Force Microscope-Scanning Electrochemical Microscope (AFM-SECM)
Published on: February 10, 2021
Advances in the application of scanning electrochemical microscopy to bioanalytical systems
William S Roberts1, Daniel J Lonsdale, John Griffiths
1Cranfield Health, Cranfield University, Barton Road, Silsoe, Bedfordshire MK45 4DT, United Kingdom.
Abstract:
Scanning electrochemical microscopy (SECM) is a powerful surface characterisation technique that allows for the electrochemical profiling of surfaces with sub micrometer resolution. While SECM has been most widely used to electrochemically study and profile non-biological surfaces and processes, the technique has in recent years, been increasingly used for the study of biological systems - and this is the focus of this review. An overview of SECM and how the technique may be applied to the study of biological systems will first be given. SECM and its application to the study of cells, enzymes and DNA will each be considered in detail. The review will conclude with a discussion of future directions and scope for further developments and applications.
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