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Related Experiment Video

Updated: Jul 11, 2026

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Midodrine improves ejaculation in spinal cord injured men.

J M Soler¹, J G Previnaire, P Plante

¹Laboratoire d'urodynamique et de sexologie, Centre Bouffard Vercelli, Cap Peyrefite, Cerbère, France.

The Journal of Urology

|September 18, 2007

Summary

Midodrine effectively aids ejaculation in men with spinal cord injuries. This alpha1-adrenergic agonist, when combined with penile vibratory stimulation, offers a safe treatment option for anejaculation.

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Area of Science:

Neuroscience
Pharmacology
Urology

Background:

Spinal cord injury (SCI) frequently causes anejaculation, impacting fertility and quality of life.
Penile vibratory stimulation (PVS) is a common treatment, but efficacy varies.
Pharmacological adjuncts are needed to improve PVS outcomes in SCI patients.

Purpose of the Study:

To evaluate the efficacy and safety of oral midodrine as an adjunct to PVS for treating anejaculation in men with SCI.

Main Methods:

185 SCI patients with anejaculation unresponsive to PVS received midodrine (30-120 minutes prior to stimulation).
Doses were escalated weekly from 7.5 mg to a maximum of 30 mg.
Cardiovascular effects were monitored throughout the treatment protocol.

Main Results:

Antegrade or retrograde ejaculation was achieved in 64.6% (102/185) of patients.
Higher success rates were observed in patients with complete (ASIA A) and upper motor neuron lesions (above T10).
Midodrine caused a moderate increase in mean arterial pressure (max 10 mm Hg) with no significant side effects; average effective dose was 18.7 mg.

Conclusions:

Midodrine is a safe and effective adjunct therapy for PVS in managing anejaculation in men with spinal cord injuries.
The medication demonstrates a favorable safety profile, with manageable cardiovascular effects.
This approach offers a promising option for improving reproductive outcomes in this population.