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10:26
Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology
Published on: August 18, 2023
A molecular epidemiological study of rabies in Puerto Rico.
Susan A Nadin-Davis1, Jafet Velez, Carlos Malaga
1Rabies Center of Expertise, Ottawa Laboratory-Fallowfield, Canadian Food Inspection Agency, 3851 Fallowfield Road, Ottawa, K2H 8P9 Canada. nadindaviss@inspection.gc.ca
Virus Research
|September 18, 2007
Summary
Rabies in Puerto Rico, primarily in mongooses, shows two distinct variants likely from independent introductions. These viruses are linked to North American skunk strains, not Cuban mongoose strains.
Area of Science:
- Veterinary Virology
- Molecular Epidemiology
- Zoonotic Diseases
Background:
- The mongoose is the primary reservoir for rabies in Puerto Rico.
- Understanding rabies virus origins and spread is crucial for disease control.
Purpose of the Study:
- To investigate the molecular epidemiology of rabies viruses in Puerto Rico.
- To determine the origins and relationships of circulating rabies variants.
Main Methods:
- Molecular epidemiological analysis of rabies viruses from Puerto Rico in 1997.
- Phylogenetic analysis to assess viral relationships and origins.
Main Results:
- Two distinct, closely related rabies virus variants were identified in Puerto Rico.
- These variants suggest two independent rabies introductions onto the island.
- Puerto Rican variants are related to North American skunk strains, part of the cosmopolitan lineage.
Conclusions:
- Rabies viruses in Puerto Rico have distinct origins, separate from those in Cuba.
- Independent introductions and regional circulation patterns shape rabies epidemiology in the Caribbean.
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