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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

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Related Experiment Video

Updated: Jul 11, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Discordance of longitudinal changes in bone density between densitometers.

S A Frost1, N D Nguyen, J R Center

  • 1Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, NSW, Australia.

Bone
|September 18, 2007
PubMed
Summary

GE Lunar densitometers show high agreement for single bone mineral density (BMD) measurements. However, significant differences in tracking longitudinal BMD changes were observed between GE Lunar Prodigy and DPX devices.

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Published on: September 28, 2017

Area of Science:

  • Osteoporosis diagnosis and management
  • Bone mineral density (BMD) assessment
  • Dual-energy X-ray absorptiometry (DXA) technology

Background:

  • Dual-energy X-ray absorptiometry (DXA) is crucial for diagnosing and managing osteoporosis.
  • This study compares bone mineral density (BMD) measurements between GE Lunar Prodigy and DPX densitometers.

Purpose of the Study:

  • To evaluate the concordance of BMD measurements between GE Lunar Prodigy and DPX densitometers.
  • To assess the agreement in longitudinal BMD changes measured by these two densitometers.

Main Methods:

  • BMD measurements at the lumbar spine and femoral neck were taken from 135 individuals using both GE Lunar DPX and Prodigy densitometers.
  • Follow-up BMD measurements were obtained from 56 individuals after an average of 2.2 years.

Main Results:

  • High concordance (r > 0.96) was found for single BMD measurements between the two densitometers.
  • Significant discordance was observed in longitudinal BMD changes at the lumbar spine (p=0.002).
  • No significant difference was found in the rate of change at the femoral neck (p=0.95).

Conclusions:

  • GE Lunar Prodigy and DPX densitometers show high agreement for single BMD measurements.
  • Discordance in assessing longitudinal BMD changes necessitates caution when using different densitometers in multi-center studies.
  • These findings impact the evaluation of osteoporosis treatment response across different DXA devices.