Related Experiment Video
Updated: Jul 11, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Timing of hepatitis B vaccination: its effect on vaccine response in health care workers
Meritxell Sabidó1, Laura Gavaldà, Noemí Olona
1Department of Preventive Medicine and Public Health, Hospital Universitari de Bellvitge, Crta. Feixa Llarga s/n, L'Hospitalet de Llobregat 08907, Spain. xellsabido@gmail.com
Abstract:
We assessed the effect of timing and other biological variables on immune response among health care workers (HCW) vaccinated with hepatitis B vaccine. A total of 2.058 HCW received three doses and were tested for anti-HBs within 6 months. 92.2% of the HCW had evidence of seroprotection. Multivariable analysis showed that controlling for age, the estimated non-response OR associated with a delayed second dose was 2.16 (95% CI: 1.46, 3.18, p=0.004). We found a decreasing response rate with increasing age. Particular attention should be given to those HCW who are late for the second vaccine dose and to older subjects.
Related Concept Videos
Vaccinations
Hepatitis
Cross-reactivity
Smallpox
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Viral Hepatitis I: Introduction