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Related Experiment Video

Updated: Jul 11, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Infection in systemic lupus erythematosus.

M Khalifa1, N Kaabia, F Bahri

  • 1Department of Internal Medicine and Infectious Diseases, University Hospital Center Farhat-Hached, 4000 Sousse, Tunisia. mabrouk.khalifa@rns.tn

Medecine Et Maladies Infectieuses
|September 18, 2007
PubMed
Summary

Systemic lupus erythematosus (SLE) patients frequently experience severe infections. Corticosteroid therapy is a significant risk factor for these infections in adults with SLE.

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Last Updated: Jul 11, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Infections are a major cause of mortality in patients with systemic lupus erythematosus (SLE).
  • Understanding infection prevalence, characteristics, and risk factors is crucial for managing SLE patients.

Purpose of the Study:

  • To determine the prevalence and nature of infections in adult SLE patients.
  • To identify risk factors associated with infection development in SLE.

Main Methods:

  • A retrospective descriptive study analyzing charts of 75 adult SLE patients from 1990-2004.
  • Comparison of patients with infections to a control group.
  • Logistic regression analysis to identify significant risk factors for infection.

Main Results:

  • 57.5% of SLE patients experienced 82 infectious episodes; 80% were severe.
  • Common infections included urinary tract (28%), skin/soft tissue (26.8%), and respiratory (18.3%).
  • Corticosteroid therapy was the only statistically significant risk factor for infection after multivariate analysis.

Conclusions:

  • Infections are highly prevalent and severe in SLE patients.
  • Corticosteroid use is a key risk factor necessitating careful monitoring and management in SLE patients to prevent infection.