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166Holmium-containing glass for internal radiotherapy of tumors
R F Brown1, L C Lindesmith, D E Day
1Department of Life Sciences, University of Missouri-Rolla 65401.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1991
Abstract:
Aluminosilicate glass containing the beta-emitter 166Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 microns fragments of 166Ho glass (200 microCi/tumor). The results suggest that 166Ho glass would be an effective modality for deposition of intense beta- radiation for localized internal radiotherapy of tumors.