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Updated: Jul 11, 2026

Measuring Endoplasmic Reticulum Stress and Unfolded Protein Response in HIV-1 Infected T-Cells and Analyzing its Role in HIV-1 Replication
Published on: June 14, 2024
[Endoplasmic reticulum stress--common pathomechanism of different diseases?]
1Semmelweis Egyetem Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet Budapest Pf. 260. 1444. mandl@puskin.sote.hu
Abstract:
The endoplasmic reticulum (ER) is a dominant metabolic compartment in the maintenance of intracellular homeostasis and plays a decisive role in adaptation to changes of the extra- and intracellular environment. Various stressors (e.g. disturbances of intracellular calcium balance, hypoglycaemia, hypoxia, altered redox homeostasis, virus infection) affect the protein folding in the ER lumen, resulting in an accumulation of unfolded proteins. They cause the activation of ER specific signaling pathways called unfolded protein response (UPR). Activated UPR pathways have been demonstrated in various diseases the etiology of which is totally different (diabetes, neurodegenerative diseases, hepatitis etc), therefore, UPR represents a common pathomechanism. Understanding of ER stress related events can open new perspectives to improve the current therapy.
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