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Taking ACE inhibitors during early pregnancy: is it safe?
Joel G Ray1, Marian J Vermeulen, Gideon Koren
1Department of Medicine, University of Toronto, Toronto, Canada.
Question:
I knew that angiotensin-converting enzyme (ACE) inhibitors were risky to use during late pregnancy because they can cause renal shutdown in the fetus. Recently I heard of a study that claimed first-trimester exposure (when many patients still are unaware of their pregnancies) can also cause major malformations. Is this proven?
Answer:
A recent study did suggest an increased risk of malformations after first-trimester exposure to ACE inhibitors among women treated for hypertension. We believe this study had serious limitations that preclude drawing any conclusions at present.
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