Effect of therapy on serum zinc and copper in primary complex of children

Tuberculosis is a global problem especially in children, more so because of the difficulty in the diagnosis of the disease. There are about 0.5 million deaths every year by this disease, worldwide. There are some reports that, during the disease, there are changes in serum concentrations of zinc and copper, which reach towards normal levels during treatment. Such data for children are scarce, especially in reference to India. Our study indicates that there is an insignificant to significant rise in serum zinc levels in various age groups of children after antitubercular therapy (mean 61.89 +/- 3.21 to 65.24 +/- 3.60 microg/dl) and significant fall in serum copper levels in different age groups of children (mean 129.96 +/- 3.18 to 124.91 +/- 3.48 microg/dl). The Cu/Zn ratio also changed significantly from 2.11 +/- 0.12 to 1.92 +/- 0.12. Because evaluation of available diagnostic criteria for primary complex in children has been found to have high sensitivity, and although this criterion is presently not recommended for diagnosis of primary complex of children, further research can prove its utility in diagnosis and treatment of this disease.