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Updated: Jul 11, 2026

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils
Published on: November 11, 2025
Relationship between diseases accompanied by tissue destruction and granulocytes with surface adrenergic receptors
Toru Abo1, Toshihiko Kawamura, Hiroki Kawamura
1Department of Immunology, Niigata University School of Medicine, Niigata, 951-8510, Japan. immunol2@med.niigata-u.ac.jp
Abstract:
It is well-known that physiological phenomena and certain diseases, including neonatal granulocytosis, age-associated granulocytosis, periodontitis, pancreatitis, Crohn's disease, ulcerative colitis, hemorrhoids, endometriosis, and NSADs-enteritis, are accompanied by tissue destruction and granulocytosis. We investigated what is a key factor connecting tissue destruction and granulocytosis, attention being focused on adrenergic receptors on granulocytes and stress-induced sympathetic nerve stimulation. If we introduce the concept that "granulocytosis and subsequent tissue destruction are induced by sympathetic nerve stimulation," the mechanisms underlying many physiological phenomena and the etiology of several uncurable diseases in humans can be clearly understood.
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