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Updated: Jul 11, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Interleukin-17 in inflammatory skin disorders.

Astrid J van Beelen¹, Marcel B M Teunissen, Martien L Kapsenberg

¹Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Current Opinion in Allergy and Clinical Immunology

|September 18, 2007

Summary

Interleukin-17 (IL-17) producing CD4+ T helper (Th17) cells are crucial in chronic inflammatory skin diseases. While IL-17 plays a role in psoriasis and contact hypersensitivity, its role in atopic dermatitis remains unclear.

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Last Updated: Jul 11, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Area of Science:

Immunology
Dermatology

Background:

A novel subset of T helper cells, Th17 cells, producing IL-17 has been identified.
These cells are distinct from previously known Th1 and Th2 cells.

Purpose of the Study:

To investigate the association between Th17 cells and inflammatory skin diseases.
To elucidate the role of IL-17 in the pathogenesis of specific skin conditions.

Main Methods:

Review of current scientific literature on IL-17 and Th17 cells.
Analysis of the role of IL-17 in psoriasis, contact hypersensitivity, and atopic dermatitis.

Main Results:

Th17 cells are essential for defense against bacterial pathogens.
Th17 cells are implicated in the pathogenesis of chronic inflammatory diseases previously attributed to Th1 cells.
IL-17 appears to be important in the pathology of psoriasis and contact hypersensitivity.

Conclusions:

The role of IL-17 in atopic dermatitis requires further investigation.
Th17 cells are significantly involved in the pathogenesis of certain inflammatory skin diseases, including psoriasis and contact hypersensitivity.