Related Experiment Video
Updated: Jul 11, 2026
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
Orthokeratology-related infectious keratitis: a case series
Elaine W L Chee1, Lim Li, Donald Tan
1Singapore National Eye Centre, Singapore Eye Research Institute, Singapore.
Purpose:
To describe five patients who developed infectious keratitis after the use of overnight orthokeratology contact lenses.
Methods:
Retrospective case report of five patients with infectious keratitis seen in Singapore National Eye Centre between 2001 and 2006.
Results:
Five children between the ages of 9 and 14 years, who wore their lenses for an average of 1.5 months before developing orthokeratology-related infectious keratitis, were seen and treated at the Singapore National Eye Centre. All five patients had cultures that were positive for Pseudomonas aeruginosa. They were treated with fortified cefazolin (50 mg/mL) and gentamicin (14 mg/mL) and responded well, with resolution of the infectious keratitis. Although most patients had a best-corrected visual acuity of 20/40 or better after the resolution of the acute infection, they all showed a central or paracentral residual scar.
Conclusions:
Because of the safety issues involved, orthokeratology should be used with caution in children.
