Speed-mapping quantitative trait loci using microarrays

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Chao-Qiang Lai1, Jeff Leips, Wei Zou

  • 1Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging, Nutrition and Genomics, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA. chaoqiang.lai@ars.usda.gov

Nature Methods
|September 18, 2007
PubMed

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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...