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Published on: March 22, 2012
Platelia Aspergillus assay for diagnosis of disseminated histoplasmosis
S Ranque1, R Pelletier, A Michel-Nguyen
1Laboratoire de Parasitologie-Mycologie, AP-HM Timone, Marseille Cedex 5, France. stephane.ranque@ap-hm.fr
Abstract:
The Platelia Aspergillus assay tested positive in 8 of 11 patients with disseminated histoplasmosis. While other available methods for diagnosis have several drawbacks, this cross-reactivity is particularly valuable in the perspective of practitioners outside the USA who cannot use the test detecting antigen of Histoplasma capsulatum.
Insights
The Platelia Aspergillus assay can aid in diagnosing disseminated histoplasmosis in patients outside the USA. This test shows cross-reactivity, offering a valuable alternative when Histoplasma capsulatum antigen tests are unavailable.
Area of Science:
- Medical Mycology
- Clinical Diagnostics
Background:
- Disseminated histoplasmosis diagnosis is challenging, especially outside the USA.
- Current diagnostic methods for histoplasmosis have limitations.
Purpose of the Study:
- To evaluate the utility of the Platelia Aspergillus assay for diagnosing disseminated histoplasmosis.
- To assess the cross-reactivity of the Platelia Aspergillus assay in histoplasmosis patients.
Main Methods:
- The Platelia Aspergillus assay was performed on patients with disseminated histoplasmosis.
- Results were compared to other diagnostic methods.
Main Results:
- The Platelia Aspergillus assay yielded positive results in 8 out of 11 (73%) patients with disseminated histoplasmosis.
- This assay demonstrated valuable cross-reactivity for diagnosing histoplasmosis.
Conclusions:
- The Platelia Aspergillus assay is a potentially useful diagnostic tool for disseminated histoplasmosis, particularly in regions where specific Histoplasma antigen tests are inaccessible.
- Cross-reactivity of the assay provides a viable alternative diagnostic approach.
