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Updated: Jul 11, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

[Voriconazole for the therapy of mycoses in recipients of solid organ transplants]

Amparo Solé1, Miguel Salavert

  • 1Unidad de Trasplante Pulmonar, Hospital Universitario La Fe, Valencia, Spain.

Revista Iberoamericana De Micologia
|September 19, 2007
PubMed

Insights

Invasive fungal infections pose a significant threat to solid organ transplant recipients. Voriconazole offers improved antifungal activity and pharmacokinetics, enhancing treatment outcomes for these vulnerable patients.

Area of Science:

  • Mycology
  • Transplant Infectious Diseases
  • Pharmacology

Context:

  • Invasive fungal infections (IFI) are a major cause of morbidity and mortality in solid organ transplant (SOT) recipients.
  • IFI incidence in SOT varies from 5-42% depending on the transplanted organ.
  • IFI-related mortality rates range from 25-95% based on fungal type and localization.

Purpose:

  • To evaluate the role of new antifungal agents in improving the prognosis of IFIs in SOT recipients.
  • To highlight the pharmacological advantages of voriconazole in managing IFIs.
  • To assess the clinical efficacy of voriconazole in SOT patients.

Summary:

  • Voriconazole introduction has improved management strategies for IFIs in SOT.
  • It exhibits broad-spectrum activity against classical and emerging fungal pathogens.
  • Key advantages include favorable pharmacokinetic/pharmacodynamic properties, ease of administration, and reduced adverse effects.

Impact:

  • Voriconazole has enhanced the therapeutic arsenal for IFIs in SOT.
  • Improved treatment outcomes and reduced mortality associated with IFIs in SOT.
  • Facilitates better management of both common and rare fungal infections in transplant patients.

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