Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emerging drugs for epilepsy.

Patrick Kwan1, Martin J Brodie

  • 1The Chinese University of Hong Kong, Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China. patrickkwan@cuhk.edu.hk

Expert Opinion on Emerging Drugs
|September 19, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do the third-generation antiseizure medications provide the "magic bullet" for drug-resistant epilepsy? Focus on cenobamate.

Epilepsia·2025
Same author

Interim analysis of the long-term efficacy and safety of azetukalner in an ongoing open-label extension study following a phase 2b clinical trial (X-TOLE) in adults with focal epilepsy.

Epilepsia open·2025
Same author

The impact of COVID-19 on people with epilepsy: Global results from the coronavirus and epilepsy study.

Epilepsia open·2024
Same author

Editorial: Epidemiology of epilepsy and seizures.

Frontiers in epidemiology·2024
Same author

Work productivity, quality of life, and care needs: An unfolding epilepsy burden revealed in the Australian Epilepsy Project pilot study.

Epilepsia open·2024
Same author

Comparative effectiveness of digital mental healthcare models for adults with epilepsy: A study protocol of a randomized controlled trial.

Epilepsia open·2024
Same journal

σ<sub>1</sub> receptor agonists: the new trend or an emerging therapeutic option?

Expert opinion on emerging drugs·2026
Same journal

Obefazimod (ABX464) for moderate-to-severe Crohn's disease: clinical development of a novel oral therapeutic approach.

Expert opinion on emerging drugs·2026
Same journal

Evaluating emerging amyloid-β centric drugs for the treatment of Alzheimer's disease.

Expert opinion on emerging drugs·2026
Same journal

Emerging treatment options for chronic obstructive pulmonary disease: a look into 2026 and beyond.

Expert opinion on emerging drugs·2026
Same journal

Beyond triptans in menstrual migraine: the emerging role of CGRP-targeted therapies.

Expert opinion on emerging drugs·2026
Same journal

Acute management of adult MOG antibody-associated disease: therapeutic choices and clinical outcomes.

Expert opinion on emerging drugs·2026
See all related articles

New antiepileptic drugs (AEDs) are crucial as many epilepsy patients remain uncontrolled with current treatments. Research focuses on novel compounds to improve efficacy and reduce adverse reactions for better seizure management.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Epilepsy impacts approximately 1% of the global population.
  • Existing antiepileptic drugs (AEDs) are insufficient for over one-third of patients, leading to uncontrolled seizures.
  • Uncontrolled epilepsy results in significant mortality, physical harm, psychosocial issues, and economic burdens.

Purpose of the Study:

  • To review the unmet need for novel epilepsy treatments.
  • To discuss emerging antiepileptic compounds in clinical development.
  • To highlight strategies for developing more effective epilepsy therapies.

Main Methods:

  • Review of current literature on epilepsy treatment limitations.
  • Analysis of ongoing drug development strategies, including structural modification and novel target identification.

Related Experiment Videos

  • Examination of preclinical drug screening in animal models.

    • Main Results:

    • Current AEDs have limitations in efficacy and adverse reaction profiles.
    • Various strategies are being employed to develop new AEDs.
    • Several novel compounds are progressing through clinical trials.

    Conclusions:

    • There is a critical need for new antiepileptic treatments with improved efficacy and safety.
    • Emerging compounds show promise in addressing the limitations of current therapies.
    • The ultimate goal is to develop agents that prevent seizures and halt epilepsy progression.