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Prothrombotic risk factors in children with hemiplegic cerebral palsy

Nesrin Senbil1, Deniz Yüksel, Deniz Yilmaz

  • 1Department of Child Neurology, Dr Sami Ulus Children's Hospital, Ankara, Turkey. senbilon@yahoo.com

Pediatrics International : Official Journal of the Japan Pediatric Society
|September 19, 2007
PubMed

Insights

Children with hemiplegic cerebral palsy (CP) often have prothrombotic risk factors, with over half showing coagulation abnormalities. Early evaluation for these coagulopathic abnormalities is crucial in managing hemiplegic CP.

Area of Science:

  • Pediatric Neurology
  • Hematology
  • Genetics

Background:

  • Hemiplegic cerebral palsy (CP) is a neurological disorder.
  • Prothrombotic risk factors may be associated with CP.
  • Understanding these factors is important for patient management.

Purpose of the Study:

  • To investigate the prevalence of prothrombotic risk factors in hemiplegic cerebral palsy (CP).
  • To identify specific inherited and acquired coagulopathy risk factors in this patient group.

Main Methods:

  • Tested 23 hemiplegic CP patients for inherited and acquired prothrombotic risk factors.
  • Excluded methylene tetrahydrofolate reductase (MTFR) polymorphism from testing.

Main Results:

  • 56.5% of patients had at least one coagulation abnormality; 13% had two.
  • Identified factor V Leiden mutation (21.7%), protein C deficiency (21.7%), elevated lipoprotein-a (13%), G20210A prothrombin mutation (8.7%), and protein S deficiency (4.3%).
  • Obstetric problems (56.5%) and co-occurring conditions like infection and congenital heart disease were noted.

Conclusions:

  • Children with hemiplegic CP frequently exhibit coagulopathic abnormalities.
  • Evaluation for these abnormalities is recommended for children diagnosed with hemiplegic CP.
Abstract

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