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Ganoderma lucidum and its pharmaceutically active compounds.

Bojana Boh1, Marin Berovic, Jingsong Zhang

  • 1Faculty of Natural Sciences and Engineering, University of Ljubljana, Vegova 4, 1000 Ljubljana, Slovenia.

Biotechnology Annual Review
|September 19, 2007
PubMed
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Ganoderma lucidum cultivation is detailed, focusing on its pharmacological compounds like triterpenoids and polysaccharides. These compounds show significant health benefits, including anti-tumor and protective effects against cell damage.

Area of Science:

  • Mycology
  • Pharmacology
  • Biotechnology

Background:

  • Ganoderma lucidum is a rare, wood-degrading mushroom with diverse pharmacological properties.
  • Artificial cultivation methods include wood logs, sawdust, and bioreactors for both fruiting bodies and mycelia.
  • Key bioactive compounds are triterpenoids and polysaccharides, responsible for its medicinal effects.

Purpose of the Study:

  • To review the cultivation techniques for Ganoderma lucidum.
  • To highlight the pharmacological constituents and their health benefits.
  • To emphasize the biotechnological potential of Ganoderma lucidum.

Main Methods:

  • Review of existing literature on Ganoderma lucidum cultivation.
  • Analysis of pharmacological studies on its active compounds.

Related Experiment Videos

  • Discussion of biotechnological approaches for biomass production.

    • Main Results:

    • Ganoderma lucidum can be cultivated using various methods, including submerged cultivation in bioreactors.
    • Triterpenoids exhibit hepatoprotective, anti-hypertensive, and anti-tumor activities.
    • Polysaccharides, particularly beta-d-glucans, demonstrate anti-tumor effects via immunomodulation and anti-angiogenesis, alongside antioxidant properties.

    Conclusions:

    • Ganoderma lucidum is a valuable medicinal mushroom with a wide range of therapeutic applications.
    • Effective cultivation and biotechnological production are crucial for harnessing its pharmacological potential.
    • Further research into its bioactive compounds can lead to novel therapeutic strategies.