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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...

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Related Experiment Video

Updated: Jul 11, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Targeted agents: the rules of combination.

Eunice L Kwak1, Jeffrey W Clark, Bruce Chabner

  • 1Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA. ekwak@partners.org

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|September 19, 2007
PubMed
Summary
This summary is machine-generated.

Molecularly targeted agents (MTAs) show promise in cancer treatment. This review explores combining MTAs with other therapies to maximize effectiveness and presents FDA-approved options.

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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Area of Science:

  • Oncology
  • Pharmacology
  • Drug Development

Background:

  • Molecularly targeted agents (MTAs) have transformed cancer therapy.
  • The efficacy of single-agent MTAs has spurred interest in combination strategies.

Purpose of the Study:

  • To review Food and Drug Administration (FDA)-approved molecularly targeted agents.
  • To provide a framework for optimizing MTA combinations in cancer treatment.

Main Methods:

  • Literature review of FDA-approved MTAs.
  • Analysis of existing data on MTA combinations.
  • Development of a conceptual framework for combination therapy.

Main Results:

  • An overview of currently available FDA-approved MTAs is presented.
  • Key considerations for combining different MTAs and conventional chemotherapies are outlined.

Conclusions:

  • Strategic combinations of MTAs hold potential for enhanced therapeutic effects in cancer.
  • A systematic approach is needed to guide the development of effective MTA combination regimens.