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Updated: Jul 11, 2026

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
[Successful desensitization using cisplatin after carboplatin-associated hypersensitivity reactions in 3 cases with
Masayoshi Hosaka1, Yasuhiko Ebina, Masashi Moriwaki
1Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine.
Abstract:
The standard chemotherapy for ovarian carcinoma is paclitaxel and carboplatin concomitant therapy. This combination is so frequently administered that a carboplatin-associated hypersensitivity reaction may occur after long-term treatment. Recently, we experienced carboplatin-associated hypersensitivity reactions in three cases. They showed symptoms of tachycardia, chest tightness, and dyspnea. We report these cases that could be readministered platinum agent using the cisplatin desensitization method. This method was relatively safe and successful for patients with platinum-sensitive disease.
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