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Updated: Jul 11, 2026

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
Published on: March 29, 2017
Long-chain n-3 fatty acids in lipid rafts: implications for anti-inflammatory effects
1Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. garattini@marionegri.it
Abstract:
Emerging evidence indicates that dietary intake of long-chain n-3 fatty acids changes the lipid composition of lipid rafts and caveolae, which are cholesterol- and sphingolipid-rich microdomains of the plasma membrane. Membrane proteins that are involved in signal transduction events relevant to inflammation are specifically localised to these microdomains. By altering the lipid composition of the membrane microdomains, n-3 fatty acids have the potential to modulate these signalling events and exert anti-inflammatory actions.
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