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Related Experiment Videos

Prolyl cis-trans isomerization as a molecular timer.

Kun Ping Lu1, Greg Finn, Tae Ho Lee

  • 1Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 1030, Boston, Massachusetts 02215, USA. klu@bidmc.harvard.edu

Nature Chemical Biology
|September 19, 2007
PubMed
Summary
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Proline

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Enzymology

Background:

  • Proline's unique cis and trans conformations enable it to function as a molecular switch.
  • Prolyl cis-trans isomerization is a slow process, often requiring catalysis by peptidyl prolyl cis-trans isomerases (PPIases).
  • PPIases like cyclophilins and FK506-binding proteins have known roles beyond isomerization, including as drug targets.

Purpose of the Study:

  • To highlight the regulatory significance of enzyme-catalyzed prolyl cis-trans isomerization in human physiology and pathology.
  • To underscore the discovery of Pin1 (phosphorylation-specific prolyl isomerase) as a key enzyme in this process.
  • To explore the potential of prolyl cis-trans isomerization as a molecular timer and therapeutic target.

Main Methods:

Related Experiment Videos

  • Review of existing literature on proline conformations and isomerization.
  • Analysis of the roles of various peptidyl prolyl cis-trans isomerases, including Pin1.
  • Discussion of phosphorylation-dependent and independent isomerization mechanisms.

    • Main Results:

    • Prolyl cis-trans isomerization is a critical regulatory mechanism in biological systems.
    • Pin1's discovery revealed the importance of phosphorylation-dependent isomerization.
    • Both types of prolyl isomerization can function as molecular timers, controlling cellular processes.

    Conclusions:

    • Enzyme-catalyzed prolyl cis-trans isomerization is a vital regulatory mechanism.
    • Prolyl isomerization acts as a molecular timer, influencing cellular process dynamics.
    • Prolyl cis-trans isomerization represents a promising new target for therapeutic interventions.