Related Experiment Video
Updated: Jul 11, 2026
Automated Impactor for Contusive Spinal Cord Injury Model in Mice
Published on: January 19, 2024
Early adaptive changes in chronic paraplegic mice: a model to study rapid health degradation after spinal cord injury
R-V Ung1, N P Lapointe, P A Guertin
1Neuroscience Unit, CHUL Research Center, Quebec City, Quebec, Canada.
Study Design:
Literature review.
Objective:
To describe quantitatively some of most important anatomic, systemic, and metabolic changes occurring soon (one month) after spinal cord trauma in mice.
Setting:
University Laval Medical Center.
Results:
Significant changes in weight, mechanical and contractile muscle properties, bone histomorphometry and biomechanics, deep-vein morphology, complete blood count, immune cell count, lipid metabolism and anabolic hormone levels were found occurring within 1 month in completely spinal cord transected (Th9/10) mice.
Conclusion:
These data reveal that many changes in mice and humans are comparable suggesting, in turn, that this model may be a valuable tool for neuroscientists to investigate the specific mechanisms associated with rapid health degradation post-SCI.
