Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.

Degenerative Disc Disease I: Introduction

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...

Degenerative Disc Disease ll: Pathophysiology

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rhinosporidiosis: the largest case series in Brazil.

Revista da Sociedade Brasileira de Medicina Tropical·2016

Same author

Prevalence of human papillomavirus in penile malignant tumors: viral genotyping and clinical aspects.

BMC urology·2015

Same author

Small airway remodeling in idiopathic interstitial pneumonias: a pathological study.

Respiration; international review of thoracic diseases·2009

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

[Brucellosis spondylodiscitis: case report].

Caroline Castro Figueira de Mello¹, Daltono Umberto de Souza, Francisco Antônio Capita Glória

¹Setor Clínica Médica, Hospital Regional de Taguatinga, Taguatinga, DF. carolinecfm@hotmail.com

Revista Da Sociedade Brasileira De Medicina Tropical

|September 19, 2007

Summary

This case report details Brucella spondylodiscitis in a farmer, diagnosed via serology and blood culture. Early diagnosis and treatment with antibiotics led to clinical improvement, highlighting the importance of recognizing this rare complication.

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Related Experiment Videos

Last Updated: Jul 11, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

Infectious Diseases
Rheumatology
Radiology

Background:

Brucellosis is a zoonotic disease with diverse clinical manifestations.
Vertebral involvement, or spondylodiscitis, is an uncommon but serious complication of brucellosis.
Diagnosis can be challenging, especially in tuberculosis-endemic areas where symptoms may overlap.

Observation:

A 56-year-old male farmer presented with systemic symptoms suggestive of brucellosis.
Diagnostic workup revealed positive serological tests (titer 1/160), positive blood culture, and elevated blood sedimentation rate.
Radiological imaging confirmed spondylodiscitis at the T8/T9 vertebral level.

Findings:

The patient was successfully treated with a combination of streptomycin, doxycycline, and rifampicin.
Clinical improvement was observed following the prescribed antibiotic regimen.
This case underscores the diagnostic utility of serology, blood cultures, and imaging in identifying Brucella spondylodiscitis.

Implications:

Early recognition and prompt treatment of Brucella spondylodiscitis are crucial to prevent long-term sequelae.
Clinicians should maintain a high index of suspicion for brucellosis in patients with vertebral infections, particularly in endemic regions.
This case highlights the importance of considering brucellosis in the differential diagnosis of spinal infections.