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[Androgen resistance related to receptor disorders]
Klinicheskaia Meditsina
|December 1, 1991
Abstract:
It is the review of literature data on various phenotypic anomalies consequent to the absent or reduced ability of the target tissues to response to androgens (A) due to defects in receptor A structure and function. Clinical forms of resistance to A, quantitative and qualitative abnormalities in hormone-receptor interaction detectable in relevant patients are described as well as markers of target tissue sensitivity to A action suggested for use in prognosticating the response to A treatment.
Insights
This review examines phenotypic anomalies caused by androgen receptor defects, impacting tissue response. It discusses clinical resistance forms and markers for predicting treatment effectiveness.
Area of Science:
- Endocrinology
- Molecular Biology
- Genetics
Context:
- Androgen insensitivity syndrome (AIS) is a spectrum of disorders.
- Defects in androgen receptor (AR) structure and function lead to impaired androgen signaling.
- Phenotypic variability in AIS ranges from disorders of sex development to mild symptoms.
Purpose:
- To review literature data on phenotypic anomalies resulting from impaired androgen receptor function.
- To describe clinical forms of androgen resistance.
- To identify markers for predicting treatment response in patients with androgen receptor defects.
Summary:
- This review synthesizes literature on phenotypic anomalies arising from absent or reduced target tissue response to androgens (A) due to androgen receptor (AR) defects.
- It details clinical manifestations of androgen resistance, including quantitative and qualitative abnormalities in hormone-receptor interactions.
- The review also proposes markers for assessing target tissue sensitivity to androgen action to aid in prognostication of treatment response.
Impact:
- Provides a comprehensive overview of androgen receptor defects and their clinical consequences.
- Highlights the importance of understanding hormone-receptor interactions for diagnosis and management.
- Offers potential biomarkers for guiding androgen replacement therapy and improving patient outcomes.