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Related Experiment Videos

Is it genomic imprinting or preferential expression?

Hasan Khatib1

  • 1Department of Dairy Science, 1675 Observatory Drive, University of Wisconsin, Madison, WI 53706, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|September 19, 2007
PubMed
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Genomic imprinting studies often overlook preferential gene expression, where one allele is stronger. This study found preferential expression in many maternally expressed imprinted genes but fewer paternally expressed ones.

Area of Science:

  • Genetics
  • Genomic Imprinting
  • Epigenetics

Background:

  • Imprinted genes exhibit parent-of-origin-specific monoallelic expression.
  • Preferential expression, where one allele is dominant, is frequently reported for imprinted genes but understudied.
  • The distinction between imprinted and preferentially expressed genes requires clarification.

Purpose of the Study:

  • To investigate the phenomenon of preferential allelic expression in imprinted genes.
  • To determine the prevalence of preferential expression in maternally versus paternally expressed imprinted genes.
  • To assess the implications of preferential expression for the definition of genomic imprinting.

Main Methods:

  • Selection of 50 mouse genes previously reported as imprinted.

Related Experiment Videos

  • Analysis of allelic expression patterns to identify instances of preferential expression.
  • Comparison of preferential expression rates between maternally and paternally expressed genes.

    • Main Results:

    • Preferential expression was observed in 21 out of 27 maternally expressed genes.
    • Only 5 out of 23 paternally expressed genes exhibited preferential expression.
    • A significant proportion of non-imprinted genes also show differential allelic expression.

    Conclusions:

    • Preferential expression is common in maternally expressed imprinted genes, challenging strict monoallelic definitions.
    • The overlap between preferential and differential allelic expression necessitates revised definitions of genomic imprinting.
    • Re-evaluation of imprinted gene counts in mammals may be required based on these findings.