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Updated: Jul 11, 2026
16:13
Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
Published on: June 13, 2011
An overview on immune system and migraine
P P Bruno1, F Carpino, G Carpino
1Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy.
European Review for Medical and Pharmacological Sciences
|September 20, 2007
Summary
The exact role of cytokines in migraine pathogenesis remains unclear, with current research showing controversial findings. This review examines recent reports on immune system involvement and cytokine modifications in migraine.
Area of Science:
- Neuroscience
- Immunology
- Pathophysiology
Background:
- Migraine pathogenesis is not fully understood.
- Evidence suggests a link between migraine and immune system modifications.
- Cytokines, key immune mediators, are implicated in neuroinflammation and pain pathways.
Purpose of the Study:
- To review and comment on recent findings regarding cytokine alterations in migraine.
- To explore the role of the immune system in the context of migraine.
- To address the controversial data on cytokine levels in migraine patients.
Main Methods:
- Literature review of recent human studies.
- Analysis of peripheral and central cytokine levels.
- Examination of the relationship between cytokines, neuroinflammation, and trigeminal nerve activation.
Main Results:
- Data on cytokine levels in migraine patients are highly controversial.
- Cytokines are suggested to mediate pain in neurovascular inflammation.
- Elevated chemokines may activate trigeminal nerves, leading to inflammation.
Conclusions:
- Conclusive evidence for the role of cytokines in migraine is currently lacking.
- Further research is needed to clarify the immune system's involvement in migraine.
- Cytokine modifications represent a potential area of investigation for migraine treatment.
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