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Updated: Jul 11, 2026
Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
Published on: August 31, 2022
Imaging of multistep human hepatocarcinogenesis
Osamu Matsui1, Tosifumi Gabata, Satoshi Kobayashi
1Department of Imaging Diagnosis and Interventional Radiology, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Insights
Hepatocellular carcinoma (HCC) screening in Japan detects early-stage tumors. Understanding sequential imaging changes in liver nodules is crucial for accurate diagnosis and treatment.
Area of Science:
- Hepatology
- Oncology
- Radiology
Background:
- Hepatocellular carcinoma (HCC) causes significant mortality in Japan, with ~32,000 deaths annually.
- Over 90% of HCC cases are linked to chronic hepatitis C or B virus infections.
- Periodic screening enables early detection of small, treatable HCC in high-risk individuals.
Purpose of the Study:
- To emphasize the importance of characterizing hepatocellular nodules detected during HCC screening.
- To highlight the necessity of understanding multistep hepatocarcinogenesis for accurate diagnosis.
- To correlate sequential changes in imaging findings with HCC development.
Main Methods:
- Review of imaging findings in patients undergoing HCC screening.
- Analysis of nodular changes within the liver parenchyma.
- Correlation of imaging characteristics with the stages of hepatocarcinogenesis.
Main Results:
- Various hepatocellular nodules are frequently detected during HCC screening.
- Characterization of these nodules is vital for early HCC diagnosis.
- Understanding sequential imaging changes aids in differentiating benign from malignant lesions.
Conclusions:
- Early detection of HCC through screening is feasible in high-risk populations.
- Accurate characterization of liver nodules requires knowledge of hepatocarcinogenesis.
- Sequential imaging analysis is key for timely and effective HCC management.
Abstract:
In Japan, there are approximately 32 000 deaths ( approximately 30 deaths per 100 000) per year due to hepatocellular carcinoma (HCC), and it is the third most common cancer in men and fifth in women. Approximately 90% of them are associated with chronic liver diseases due to hepatitis C or B virus infection. Therefore, it has become possible to detect small early stage HCC by the periodic screening in these high-risk patients group. During the screening imaging diagnosis of HCC, various kinds of hepatocellular nodules are also frequentlydetected. To characterize them is very important for the early diagnosis and treatment of HCC. For this purpose, it is necessary to understand the concept of multistep hepatocarcinogenesis and the sequential changes of imaging findings.
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