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Immunotoxicity: the risk is real.

Maryjane K Selgrade1

  • 1US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD B143-01, Research Triangle Park, NC 27711, USA. selgrade.maryjane@epa.gov

Toxicological Sciences : an Official Journal of the Society of Toxicology
|September 20, 2007
PubMed
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Rodent immunotoxicity studies accurately predict human immune system risks from environmental exposures like cigarette smoke, arsenic, and PCBs. Developmental exposure to these toxicants can increase susceptibility to disease and allergies.

Area of Science:

  • Environmental Health
  • Immunotoxicology
  • Developmental Toxicology

Background:

  • Bridging the gap between rodent immunotoxicity data and human risk assessment is crucial for public health.
  • Rodent models are increasingly recognized as predictive for human immune system responses to toxicants.

Purpose of the Study:

  • To review recent findings on the predictive value of rodent immunotoxicity data for human health risks.
  • To assess the relationship between developmental exposure to environmental toxicants and immune suppression in humans.
  • To examine the link between immune suppression and increased risk of infectious, neoplastic, or allergic diseases.

Main Methods:

  • Review of recent scientific literature focusing on immunotoxicity studies.
  • Analysis of data from human exposures to environmental toxicants in different media (air, water, food).

Related Experiment Videos

  • Evaluation of quantitative relationships between exposure levels and immune suppression markers.

    • Main Results:

    • Rodent immunotoxicity data is predictive of human immune response suppression, particularly for the developing immune system.
    • Developmental exposure to cigarette smoke, arsenic, and polychlorinated biphenyls (PCBs) is linked to immune suppression.
    • Arsenic and PCB exposures show a quantitative relationship with human immune suppression; cigarette smoke and arsenic linked to increased allergy risk.

    Conclusions:

    • Rodent immunotoxicity data provides a justified basis for concern regarding human health risks.
    • Environmental toxicants pose real risks through various exposure routes, impacting immune function and disease susceptibility.
    • Further research can be designed to investigate both immune suppression and allergic disease risks from developmental exposures.