Bacterial colonization behaviour: a new virulence strategy in urinary infections?

The urinary bladder resists bacterial colonization and infection by a number of mechanisms, one of which involves the sloughing of colonized uroepithelial cells. Pathogens which thus become detached from bladder tissue are rapidly eliminated upon voiding of urine. During a recent study of bacterial colonization by the urinary pathogen, Proteus mirabilis, we noted that it colonized glass surfaces such that organisms became widely and evenly dispersed over the surface. In contrast, Pseudomonas fluorescens, a non-pathogen in the urinary tract, did not disperse over the surface but colonized and grew in such a manner as to form small clumps or microcolonies. Other investigators have also shown that Escherichia coli, a common urinary pathogen, initially colonizes bladders in a random, widely-dispersed fashion. We propose that successful bladder pathogens will predominantly adopt colonization behaviour that enables them to widely disperse over bladder tissue and, in so doing, avoid being cleared by the desquamation of uroepithelial cells. Colonization behaviour would therefore represent a previously uncharacterized virulence strategy.