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Updated: Jul 11, 2026
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Metabolomics and metabolite profiling: past heroes and future developments.
W J Griffiths1, K Karu, M Hornshaw
1The School of Pharmacy, University of London, 29 39 Brunswick Square, London, UK.
European Journal of Mass Spectrometry (Chichester, England)
|September 20, 2007
Summary
This study reviews mass spectrometry-based metabolomic strategies, tracing their evolution from metabolite profiling. It highlights targeted metabolomics, specifically steroidomics in the brain, and future research directions.
Area of Science:
- Post-genomic science, focusing on metabolomics and proteomics.
- Analytical chemistry and mass spectrometry applications in biological research.
Background:
- The completion of genome sequencing has shifted research towards understanding gene function and its products.
- Metabolomics has emerged as a critical field for studying small molecules in biological systems.
- Previous 'metabolite profiling' laid the groundwork for current metabolomic approaches.
Purpose of the Study:
- To provide an overview of mass spectrometry-based metabolomic strategies.
- To discuss the historical development of metabolomics.
- To present future methodological and technological directions in the field.
Main Methods:
- Review of mass spectrometry-based techniques for metabolomic analysis.
- Discussion of the evolution from metabolite profiling to modern metabolomics.
- Presentation of data from targeted metabolomics research.
Main Results:
- An overview of current mass spectrometry-based metabolomic strategies is presented.
- The progression from metabolite profiling to advanced metabolomics is detailed.
- Specific data on targeted metabolomics, focusing on brain steroidomics, is highlighted.
Conclusions:
- Mass spectrometry is a key technology driving advancements in metabolomics.
- Targeted metabolomics, such as steroidomics, offers powerful insights into biological systems.
- Continued methodological and technological innovation is crucial for future metabolomic research.
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