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Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...

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Related Experiment Video

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Histochemistry for placenta research: theory and application.

Toshihiro Takizawa1, Hidetaka Eguchi, Shigeki Namimatsu

  • 1Department of Molecular Anatomy, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. t-takizawa@nms.ac.jp

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
|September 20, 2007
PubMed
Summary

Advanced histochemical techniques enhance understanding of placenta function in health and disease. These methods, including laser microdissection and novel microscopy, offer profound insights into placental morphology and cell biology.

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Area of Science:

  • Histochemistry
  • Placental Biology
  • Cell Biology

Background:

  • Histochemical techniques are crucial for advancing placental and cell biology research.
  • Understanding placenta morphology is key to diagnosing and treating diseases.

Purpose of the Study:

  • To review recent advances in histochemical technologies.
  • To demonstrate how these methods improve understanding of placental function in health and disease.

Main Methods:

  • Tissue-based polymerase chain reaction with laser microdissection.
  • Novel antigen retrieval using citraconic anhydride and heating.
  • Immunohistochemistry, confocal microscopy, and high-resolution immunofluorescence on ultrathin cryosections.

Main Results:

  • Detailed analysis of Lewis-related antigen expression and galectin-1 binding in the human placenta.
  • Confocal microscopy elucidated IgG transport mechanisms in placental trophoblasts.
  • High-resolution microscopy revealed intricate placental structures.

Conclusions:

  • Advanced histochemical techniques offer powerful tools for placental research.
  • These methods significantly improve the understanding of placenta morphology and function.
  • The reviewed techniques have profound implications for diagnosing and treating placental-related diseases.