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Updated: Jul 11, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
ADAM33, a new candidate for psoriasis susceptibility.
Fabienne Lesueur1, Tiphaine Oudot, Simon Heath
1Centre National de Génotypage, Evry, France. lesueurf@iarc.fr
Plos One
|September 20, 2007
Summary
Researchers identified ADAM33 as a novel susceptibility gene for psoriasis, a chronic skin condition. This finding, independent of the PSORS1 locus, suggests common genetic factors may influence multiple immune-mediated diseases.
Area of Science:
- Genetics
- Dermatology
- Immunology
Background:
- Psoriasis is a chronic skin disorder with complex genetic underpinnings.
- Previous genome-wide scans identified a potential susceptibility locus on Chromosome 20p13, distinct from the known PSORS1 locus.
Purpose of the Study:
- To investigate the novel psoriasis susceptibility locus on Chromosome 20p13.
- To identify specific genes associated with psoriasis within this region.
Main Methods:
- Utilized a family-based association test (FBAT) to scan a 17 Mb region on Chromosome 20p13.
- Investigated 85 single nucleotide polymorphism (SNP) markers across 65 genes in 295 nuclear families.
- Focused on candidate genes near significantly associated SNPs, including ADAM33.
Main Results:
- A significant association was found between the gene ADAM33 and psoriasis (3-SNP haplotype P = 0.00004).
- This association was independent of the major psoriasis susceptibility locus, PSORS1.
- ADAM33 was previously linked to asthma, indicating shared genetic factors in immune system diseases.
Conclusions:
- ADAM33 is identified as a novel susceptibility gene for psoriasis through positional cloning.
- This discovery provides insights into the pathogenesis and natural history of psoriasis.
- Suggests common susceptibility genes may underlie various immune-mediated inflammatory conditions affecting the skin and immune system.
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