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Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe
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Direct selection on genetic robustness revealed in the yeast transcriptome.

Stephen R Proulx1, Sergey Nuzhdin, Daniel E L Promislow

  • 1Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, Iowa, United States of America. proulx@iastate.edu

Plos One
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Organisms evolve environmental and genetic robustness. This study in yeast shows genetic robustness is linked to network position, suggesting direct selection, while environmental robustness relates to fitness costs.

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Area of Science:

  • Evolutionary biology
  • Genomics
  • Systems biology

Background:

  • Evolutionary theory posits organisms develop environmental and genetic robustness.
  • Mechanisms for robustness exist, but differential genomic robustness remains unexplained.
  • Selection pressures differ: environmental robustness selection links to fitness costs, while genetic robustness selection correlates with genetic variation.

Purpose of the Study:

  • To investigate the evolutionary basis of differential genetic and environmental robustness across the yeast genome.
  • To test the congruence hypothesis versus direct selection hypothesis for robustness evolution.

Main Methods:

  • Analysis of gene expression data in Saccharomyces cerevisiae.
  • Correlation analysis between genetic robustness, environmental robustness, per-gene fitness effects, and network position.

Main Results:

  • Genetic robustness and environmental robustness are correlated in yeast, supporting the congruence hypothesis.
  • Environmental robustness correlates with per-gene fitness effects, but genetic robustness does not.
  • Genetic robustness is significantly associated with network position, indicating direct selection.

Conclusions:

  • The observed correlation between genetic and environmental robustness aligns with the congruence hypothesis.
  • Direct selection on robustness, particularly for genetic robustness, plays a role in transcriptome evolution.
  • Network position is a key factor influencing the evolution of genetic robustness.