Related Experiment Video

Updated: Jul 11, 2026

Evaluating Targeting Accuracy in the Focal Plane for an Ultrasound-guided High-intensity Focused Ultrasound Phased-array System
08:08

Evaluating Targeting Accuracy in the Focal Plane for an Ultrasound-guided High-intensity Focused Ultrasound Phased-array System

Published on: March 6, 2019

Take-home message: are we "off target"?

Valeria K Khurdayan1

  • 1Prous Science, Barcelona, Spain. journals@prous.com

Drug News & Perspectives
|September 20, 2007
PubMed

Insights

Targeted anticancer therapies show promise by blocking cancer growth. Further research is needed for optimal target identification, validation, and clinical trial design for these innovative treatments.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Targeted anticancer therapies represent a significant advancement in cancer treatment, focusing on specific molecular pathways to inhibit tumor growth and proliferation.
  • The success of tyrosine kinase inhibitors (TKIs) like imatinib, gefitinib, sorafenib, and sunitinib in clinical trials has accelerated their adoption in cancer care.

Framework:

  • The 5th International Symposium on Targeted Anticancer Therapies (TAT) convened experts to discuss critical issues in the field.
  • Key areas of focus included refining methods for target identification and validation.
  • Discussions also addressed the need for improved criteria for evaluating targeted agents in preclinical and clinical settings.

Implementation:

  • Developing more effective preclinical models is crucial for accurately assessing drug efficacy and toxicity.
  • The symposium highlighted the potential benefits of early-phase (Phase 0) clinical trials for evaluating targeted therapies.

Implications:

  • Addressing these challenges will optimize the development and application of targeted anticancer drugs.
  • Advancements in preclinical models and clinical trial design are essential for maximizing the clinical benefit of targeted therapies.

More Related Videos

Methods to Test Visual Attention Online09:44

Methods to Test Visual Attention Online

Published on: February 19, 2015

New Framework for Understanding Cross-Brain Coherence in Functional Near-Infrared Spectroscopy (fNIRS) Hyperscanning Studies05:59

New Framework for Understanding Cross-Brain Coherence in Functional Near-Infrared Spectroscopy (fNIRS) Hyperscanning Studies

Published on: October 6, 2023

Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Errors in Global Positioning System01:26

Errors in Global Positioning System

Global Positioning System (GPS) technology has revolutionized navigation and positioning, but its accuracy is often compromised by various errors. These errors, stemming from environmental, satellite, and receiver-related factors, require careful mitigation to ensure reliable performance across applications.Atmospheric ErrorsGPS signals travel through the Earth’s ionosphere and troposphere, introducing delays which affect accuracy. The ionosphere is strongly influenced by charged particles,...
Accuracy and Precision01:52

Accuracy and Precision

Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.  Highly accurate measurements...
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH301:11

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
Simpson's Rule II01:28

Simpson's Rule II

In warehouse roofing applications, corrugated or curved metal sheets are commonly used to improve structural strength, water drainage, and ventilation efficiency. To accurately estimate material requirements and optimize design parameters, engineers must determine the curved surface area of these sheets. Because the sheet profiles often repeat smoothly along their length, they can be effectively approximated by parabolic curves, enabling the use of numerical integration techniques for area...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...