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A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
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An efficient and mild bismuth triflate-catalysed three-component Mannich-type reaction.

Thierry Ollevier1, Etienne Nadeau

  • 1Département de Chimie, Université Laval, Québec, Canada. thierry.ollevier@chm.ulaval.ca

Organic & Biomolecular Chemistry
|September 20, 2007
PubMed
Summary

A new catalytic method enables aldehydes and amines to react with silyl enolates, forming Mannich-type adducts. This efficient synthesis yields beta-amino ketones and esters in high amounts.

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